منابع مشابه
HIV-1 Sequence Variation Drift, Shift, and Attenuation
that there is an exponentially growing population size (Peeters and Sharp, 2000) and highlights the evolutionary " success " of HIV-1 in humans. is recombination. This can occur when a cell that is Philadelphia, Pennsylvania 19104 dually infected with different viruses produces progeny ‡ Division of Human Biology virions with genomic RNAs from each virus, and strand-Fred Hutchinson Cancer Resea...
متن کاملHIV-1 LTR DNA sequence variation in brain-derived isolates.
Isolates of human immunodeficiency virus (HIV-1) derived from the central nervous system (CNS) display properties distinctive from blood-derived isolates, including a high incidence of macrophage tropism in CNS isolates. Macrophage tropism is a result, in part, of DNA sequence variation in the HIV-1 envelope glycoprotein gene, but evidence also exists suggesting differences in the long terminal...
متن کاملHIV-1 GAG Sequence Summaries
HIVU53175 HIVCA9 U53175 422 bp gag Braaten, D. JVI 70, 4220 (1996) Comment: This study compared the five lineages of primate immunodeficiency viruses and found that only HIV-1 group M requires cyclophilin A for replication. HIV-1 gag binds to cyclophilin A and incorporates it into virions. If this process is disrupted, virion infectivity is inhibited. Cloned isolates from clades A, B, and D of ...
متن کاملSources of variation in ancestral sequence reconstruction for HIV-1 envelope genes
We characterized the variation in the reconstructed ancestor of 118 HIV-1 envelope gene sequences arising from the methods used for (a) estimating and (b) rooting the phylogenetic tree, and (c) reconstructing the ancestor on that tree, from (d) the sequence format, and from (e) the number of input sequences. The method of rooting the tree was responsible for most of the sequence variation both ...
متن کاملRelating HIV-1 sequence variation to replication capacity via trees and forests.
The problem of relating genotype (as represented by amino acid sequence) to phenotypes is distinguished from standard regression problems by the nature of sequence data. Here we investigate an instance of such a problem where the phenotype of interest is HIV-1 replication capacity and contiguous segments of protease and reverse transcriptase sequence constitutes genotype. A variety of data anal...
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ژورنال
عنوان ژورنال: Cell
سال: 2001
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(01)00234-3